TABLE 1.

RiPPs produced by bacteria from diverse microbiome involving radical SAM enzymes (see Figures 1, 3, 6, 7 for corresponding structures).

RiPP	Bacteria	Posttranslational modification	Microbiome origin	Function	References
Darobactin	Photorhabdus sp	C–C and C–O bonds	Nematode	Antimicrobial	Imai et al. (2019)
Epipeptide	Enterococcus faecalis, Streptococcus agalactiae, Staphylococcus epidermidis	Epimerization	Human/mammalian	Antimicrobial	Benjdia et al. (2017c); Popp et al. (2020)
NxxcA	Streptococcus orisratti and S. porci	β-thioether cross-links	Mammalian	Unknown	Caruso et al. (2019a)
Polytheonamide	Theonella swinhoei	Epimerization and methylation	Marine sponge	Toxin	Hamada et al. (2005); Freeman et al. (2012); Parent et al. (2016); Parent et al. (2018)
Ruminococcin C	Ruminococcus gnavus	α-thioether cross-links	Human/mammalian	Antimicrobial	Balty et al. (2019); Chiumento et al. (2019); Balty et al. (2020)
SCIFF	Clostridia	β and γ thioether cross-links	Human/mammalian	Quorum sensing	Bruender et al. (2016); Precord et al. (2019); Chen et al. (2020)
Streptide	Streptococcus thermophilus, S. mitis	C–C bond	Human/mammalian	Unknown	Ibrahim et al. (2007); Schramma et al. (2015); Benjdia et al. (2017b)
Streptosactin (GGG)	Streptococcus constellatus, Streptococcus gordonii, Streptococcus oralis and Streptococcus parasanguinis	α-thioether cross-links	Human/mammalian	Antimicrobial	Bushin et al. (2020)
TQQ	Streptococcus suis	C–O bond	Mammalian	Unknown	Clark et al. (2019)
WGK	Streptococcus equi, S. mutans, and S. ferus	C–C bond	Human/mammalian	Unknown	Bushin et al. (2018)