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BBR improved UA excretion by regulating the mRNA and protein expression of URAT1. (A) Kidney immunohistochemical staining (400×) and (B) representative Western blots of URAT1. Quantitative analysis of (C) immunohistochemical staining and (D) Western blots results (n=3). (E) mRNA expression level of URAT1 (n=4). (F) Initial orientation of the BBR in the URAT1 active pocket. (G) Chemical interactions between BBR and URAT1. All the results are shown as mean ± SEM.
