FIGURE 1.

Mutations and overexpression of ALS-related proteins and RNA contribute to altered RNA metabolism. The pathways and processes depicted here are altered by the overexpression or mutation of ALS-related genes. While the mechanisms leading to these alterations are not all fully characterized, it is evident that many RNA metabolic pathways are dysregulated in the context of ALS. In some cases, such as C9ALS, RNA itself can have a significant impact on cellular homeostasis. Further investigation into the mechanistic links between these altered processes will be crucial to understand the initiating event(s) in ALS pathogenesis. Created with BioRender.com.