Figure 6.

Schematic model for resveratrol-stimulated LKB1-mediated phosphorylation and activation of Sirt1 in mitochondrial biogenesis and respiration. Resveratrol promotes the binding between LKB1 and Sirt1, which drives LKB1 to directly phosphorylate Sirt1 at three different residues in the C-terminal domain. LKB1-dependent phosphorylation promotes the intramolecular interaction of Sirt1 and activates its deacetylase activity. Functionally, activated Sirt1 increases mitochondrial biogenesis and respiration through deacetylation and activation of PGC-1α, a master regulator of mitochondrial function.