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. 2021 Jul 19;8:690100. doi: 10.3389/fmed.2021.690100

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Copyright © 2021 Su, Wang, Hu, Li, Guo, Zheng, Liu, Gao, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Treg cell percentage [CD4⁺], (B) Tfr-like cell percentage [CD4⁺], (E) mTfr-like cell percentage [CD4⁺], and (C) Tfh-like/Treg, (D) Tfh-like/Tfr-like, and (F) Tfh-like/mTfr-like cell ratios in the peripheral blood of RA patients and healthy controls. Data are shown as the median and interquartile range. The Mann–Whitney U test was used to compare the median values. *p < 0.05, **p < 0.01, ***p < 0.001. Tfr-like, T follicular regulatory-like; mTfr-like, memory T follicular regulatory-like; Tfh-like, T follicular helper-like; Treg, T regulatory.