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. 2021 Jul 19;12:720387. doi: 10.3389/fphar.2021.720387

FIGURE 6.

FIGURE 6

ICA induces autophagy and reduces fibrosis by down-regulating miR-192-5p expression (A–B) Relative expression of miR-192-5p in HK-2 cells treated with HG, TGF-β1 and ICA. ***p < 0.001, ****p < 0.0001 vs NG, ### p < 0.001, #### p < 0.0001 vs HG (C) Relative expression of miR-192-5p in NRK-49F cells treated with HG (30 mM) and ICA (2 μM). **p < 0.01 (D–E) Relative expression of miR-192-5p in HK-2 and NRK-49F cells transfected with miR-192-5p mimic and treated with ICA (2 μM). **p < 0.01, ***p < 0.001, ****p < 0.0001 (F–G) The expression of LC3, p62, α-SMA, Col I and FN in HK-2 and NRK-49F cells transfected with miR-192-5p mimic and treated with ICA (2 μM) (H) The relative intensity of LC3-II in NRK-49F cells was analyzed by the ChemiScope analysis software, **p < 0.01, ****p < 0.0001.