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ICA and DHT induce autophagy by reducing phosphorylated mTOR (p-mTOR) expression (A) The HK-2 cells were stimulated with HG and treated respectively with ICA (50 μM), DHT (100 nM) and rapamycin (100 nM) for 48 h, the expression of p-mTOR and mTOR was detected (B) The p-mTOR and mTOR expression in HK-2 cells transfected with miR-192-5p mimic and treated with ICA (2 μM) (C) Mechanisms for the anti-diabetic tubulointerstitial fibrosis effect of ICA.
