TABLE 3.

Multivariable analysis for the association of mean VTC with mortality in Apache IV score subgroups.

	ICU mortality		Hospital mortality
VTC variable	OR (95% CI)	p value	OR (95% CI)	p value
APACHE IV score ≤64
Continuous variable	0.995 (0.952,1.040)	0.838	0.980 (0.946,1.015)	0.257
Categorical variable
<10 mg/L	1		1
10–15 mg/L	1.486 (0.588,3.758)	0.403	0.857 (0.475,1.546)	0.609
15–20 mg/L	1.443 (0.576,3.618)	0.434	0.803 (0.446,1.449)	0.467
>20 mg/L	1.459 (0.549,3.873)	0.449	0.809 (0.423,1.550)	0.523
APACHE IV score >64
Continuous variable	1.057 (1.027,1.087)	<0.001	1.049 (1.024,1.074)	<0.001
Categorical variable
<10 mg/L	1		1
10–15 mg/L	1.724 (0.864,3.438)	0.122	1.552 (0.916,2.629)	0.102
15–20 mg/L	2.053 (1.043,4.040)	0.037	1.889 (1.125,3.172)	0.016
>20 mg/L	2.895 (1.457,5.751)	0.002	2.333 (1.371,3.970)	0.002

Multivariable model: adjusted for age (category), sex, ethnicity, BMI, CCl, the use of ventilation, dialysis, vasodepressor and vasopressor, and diagnoses at ICU admission (tumour, hepatic failure, COPD, heart failure, diabetes, gastrointestinal bleed, pancreatitis, burns, pneumonia, sepsis, and renal failure).

VTC, vancomycin trough concentration; APACHE, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; OR, odds ratio; CI, confidence interval; BMI, body mass index; CCl, creatinine clearance; COPD, chronic obstructive pulmonary disease.