TABLE 2.

Bivariate logistic regression analysis of the clinical variables associated with severity of COVID-19 (a score of 6 or more in the WHO Clinical Progression Scale).

Variable		Crudea ORb (95% CI)	p-value	Adjusteda ORb (95% CI)	p-value
Gender	Female (n = 42)	1.0	0.033
	Male (n = 73)	2.33 (1.07–5.07)
Age	<65 year (n = 48)	1.0	0.603
	≥65 (n = 67)	0.82 (0.39–1.73)
C-reactive protein	<96.8 mg/L (n = 58)	1.0	0.022	1.0	0.011
	≥96.8 mg/L (n = 41)	2.73 (1.15–6.46)		3.45 (1.33–8.91)
Shannon diversity index	≥2.25 (n = 46)	1.0	0.164	1.0	0.032
	<2.25 (n = 65)	1.72 (0.80–3.68)		2.85 (1.09–7.41)
Overweight or obese	BMI < 25 (n = 36)	1.0	0.749
	BMI ≥ 25 (n = 69)	0.88 (0.39–1.98)
Hypertension	Normal (n = 41)	1.0	0.811
	Hypertension (n = 67)	0.91 (0.42–1.99)
Diabetes	Normal (n = 62)	1.0	0.101
	Diabetes (n = 45)	1.93 (0.88–4.25)
Antibiotic therapy (last 6 months)	Without (n = 66)	1.0	0.244
	With (n = 42)	0.63 (0.29–1.37)

95% CI, 95% confidence interval; OR odds ratio; BMI, body mass index. ^aCrude ORs were calculated using univariate weighted logistic regression models. Adjusted ORs were calculated using multivariate weighted logistic regression models. Fully adjusted estimates take into account four variables (age, antibiotic therapy at least once in the last 6 months, C-reactive protein, and the Shannon diversity index) in the model (n = 96). ^bRisk (OR) of severity of COVID-19 (a score of 6 or more in the WHO Clinical Progression Scale). Bold values indicate statistical significance with a *p < 0.05.