Table 1.
Gene ontology analyses of the DEGs
| Regulation | Category | Term | Gene count | Adjusted P value | Gene symbol |
|---|---|---|---|---|---|
| Up-regulated | GOTERM_BP_ FAT | GO:0010951∼negative regulation of endopeptidase activity | 7 | 4.0E-03 | SERPINB10, SERPINB3, SERPINB4, CSTA, SERPINB13, SERPINB2, FETUB |
| GOTERM_MF_ FAT | GO:0004869∼cysteine- type endopeptidase inhibitor activity | 6 | 3.3E-05 | SERPINB3, CST2, CSTA, CST1, SERPINB13, FETUB | |
| GOTERM_MF_ FAT | GO:0002020∼protease binding | 7 | 2.3E-04 | DPP4, SERPINB3, SERPINB4, CST2, CSTA, CST1, SERPINB13 | |
| GOTERM_MF_ FAT | GO:0005198∼structural molecule activity | 7 | 1.7E-02 | CLDN22, CSTA, UPK1B, KRT4, KRT13, SPRR1B, KRT6A | |
| Down-regulated | GOTERM_BP_ FAT | GO:0002504∼antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 6 | 2.1E-07 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 |
| GOTERM_BP_ FAT | GO:0031295∼T cell costimulation | 7 | 9.2E-06 | HLA-DRB5, HLA-DRB4, CD3G, HLA-DRB3, HLA- DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0050852∼T cell receptor signaling pathway | 8 | 1.3E-05 | HLA-DRB5, HLA-DRB4, CD3G, HLA-DRB3, HLA- DRB1, SKP1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0002381∼immunoglobulin production involved in immunoglobulin mediated immune response | 4 | 1.4E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0019882∼antigen processing and presentation | 6 | 2.2E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0002455∼humoral immune response mediated by circulating immunoglobulin | 4 | 3.3E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0060333∼interferon-gamma-mediated signaling pathway | 6 | 5.7E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0006955∼immune response | 10 | 5.7E-05 | C3, CD96, HLA-DRB5, HLA-DRB4, CCL5, IGHV3-48, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0019886∼antigen processing and presentation of exogenous peptide antigen via MHC class II | 6 | 5.2E-06 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_BP_ FAT | GO:0042744∼hydrogen peroxide catabolic process | 4 | 6.1E-04 | HBB, HBA2, HBA1, DUOX2 | |
| GOTERM_BP_ FAT | GO:2001179∼regulation of interleukin-10 secretion | 3 | 6.1E-04 | HLA-DRB5, HLA-DRB4, HLA-DRB1 | |
| GOTERM_CC_ FAT | GO:0042613∼MHC class II protein complex | 6 | 2.2E-06 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FAT | GO:0071556∼integral component of lumenal side of endoplasmic reticulum membrane | 6 | 4.9E-06 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FA | GO:0030658∼transport vesicle membrane | 6 | 1.4E-06 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FAT | GO:0030669∼clathrin-coated endocytic vesicle membrane | 6 | 1.8E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FAT | GO:0012507∼ER to Golgi transport vesicle membrane | 6 | 4.1E-05 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FAT | GO:0030666∼endocytic vesicle membrane | 6 | 1.1E-04 | HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 | |
| GOTERM_CC_ FAT | GO:0032588∼trans-Golgi network membrane | 6 | 3.1E-03 | HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DPA1, HLA-DQB1 |
DEGs, differentially expressed genes.