Table 2.
KEGG pathway analyses of the DEGs
| Regulation | Pathway description | Gene count | Adjusted P value | Gene symbol |
|---|---|---|---|---|
| Up-regulated | hsa05146:Amoebiasis | 6 | 3.8E-03 | MUC2, SERPINB10, SERPINB2, SERPINB4, SERPINB13, SERPINB3 |
| Down-regulated | hsa05150:Staphylococc us aureus infection | 8 | 2.4E-08 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 |
| hsa05323:Rheumatoid arthritis | 8 | 5.10E-07 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1, CCL5, ATP6V0A4 | |
| hsa05310:Asthma | 6 | 1.20E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05332:Graft-versus-host disease | 6 | 1.50E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05140:Leishmaniasis | 7 | 1.50E-06 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05330:Allograft rejection | 6 | 1.50E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05168:Herpes simplex infection | 9 | 1.70E-06 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1, SKP1, CCL5 | |
| hsa04940:Type I diabetes mellitus | 6 | 2.30E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05322:Systemic lupus erythematosus | 8 | 2.40E-06 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1, C2 | |
| hsa04672:Intestinal immune network for IgA production | 6 | 3.70E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa04145:Phagosome | 8 | 4.30E-06 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1, ATP6V0A4 | |
| hsa05320:Autoimmune thyroid disease | 6 | 5.20E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05416:Viral myocarditis | 6 | 7.60E-06 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05152:Tuberculosis | 8 | 9.00E-05 | HLA-DQB1, HLA-DRB1, C3, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1, ATP6V0A4 | |
| hsa05321:Inflammatory bowel disease (IBD) | 6 | 1.20E-05 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa04612:Antigen processing and presentation | 6 | 2.60E-04 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05164:Influenza A | 7 | 1.00E-04 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1, CCL5 | |
| hsa05145:Toxoplasmosis | 6 | 2.00E-03 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa04514:Cell adhesion molecules (CAMs) | 6 | 4.60E-03 | HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA- DRB4, HLA-DRB5, HLA-DPA1 | |
| hsa05166:HTLV-I infection | 7 | 7.70E-03 | HLA-DQB1, CD3G, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DPA1 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes.