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. 2021 Jul 19;9:653808. doi: 10.3389/fcell.2021.653808

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Copyright © 2021 Xian, Niu, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Colorectal cancer (CRC) cells can release a large amount of exosomes containing KCNQ1OT1. (A,B) Analysis of the expression difference of KCNQ1OT1 in different tumor cell exosomes in exoRbase database. (C) Total exosome protein expression. (D) The concentration of exosomes secreted in different cells by nanoparticle tracking analysis (NTA). (E) Morphology of exosomes in each group under electron microscope. (F) Expression of exosome markers in different tumor cells. (G) The expression of KCNQ1OT1 in exosomes derived from different cells. ^∗p < 0.05 compared with the FHC-exo group.