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. 2021 Jul 19;9:653808. doi: 10.3389/fcell.2021.653808

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Copyright © 2021 Xian, Niu, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long non-coding RNA (lncRNA) KCNQ1OT1 can promote immune escape of colorectal cancer (CRC) cells. (A) The TIMER 2.0 database is used to detect the correlation between KCNQ1OT1 and CD8+ T cells. (B) The expression of KCNQ1OT1 in tumor tissues from different treatment groups in BALB/c mice. (C,D) Tumor size and weight after different treatments in BALB/c mice. (E) Immunohistochemistry was used to detect the expression of CD8 and NCR1 in tumor tissues. NCR1 was used as a marker of natural killer cells. (F) Flow cytometry is used to detect the content of CD8+ and CD4+ T cells in tumor tissues. (G) The expression of epithelial–mesenchymal transition (EMT)-related proteins. ^∗p < 0.05 compared with the NC group, N = 6.