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. 2021 Jul 19;9:653808. doi: 10.3389/fcell.2021.653808

FIGURE 6.

FIGURE 6

Long non-coding RNA (lncRNA) KCNQ1OT1 regulates tumor immune escape through programmed death-ligand 1 (PD-L1). (A) Activated T cell and SW1463 cells were cocultured in six-well plates for 7 days, and then surviving SW1463 cells were visualized by colony formation assay. (B) T cell-mediated SW1463 cell killing analysis measured by Cell Counting Kit (CCK)-8 assay. (C) Cell-mediated SW1463 cell killing analysis measured by apoptosis detection. (D) Cell-mediated SW1463 cell killing analysis measured by apoptosis detection. (E,F) PD-L1 mRNA and protein expression of SW1463 cells in different treatment groups. (G) T cell-mediated SW1463 cell killing analysis measured by CCK-8 assay. (H,I) Cell-mediated SW1463 cell killing analysis measured by apoptosis detection. ∗p < 0.05 compared with the NC/PBS group, #p < 0.05 compared with the Oe-KCNQ1OT1 group.