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. 2021 Jul 19;9:653808. doi: 10.3389/fcell.2021.653808

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Copyright © 2021 Xian, Niu, Zeng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long non-coding RNA (lncRNA) KCNQ1OT1 regulates tumor cell immune escape via miR-30a-5p/ubiquitin-specific peptidase 22 (USP22) in the in vivo assay. (A,B) Tumor size and weight after different treatments in BALB/c mice. (C) Hematoxylin–eosin staining and CD8 immunohistochemical staining were used to detect tumor proliferation and immune escape in different groups. (D) Flow cytometry is used to detect the content of CD8+ T cells in tumor tissues. (E) The expression of miR-30a-5p in tumor tissues. (F) Programmed death-ligand 1 (PD-L1) protein expression of tumor tissues in different treatment groups. ^∗p < 0.05 compared with the NC group, ^#p < 0.05 compared with the Oe-KCNQ1OT1 group, N = 6.