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. 2021 Jul 19;12:701006. doi: 10.3389/fimmu.2021.701006

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Copyright © 2021 Zhou and Jin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor immunotherapy strategies based on B7-H3. (A) Targeting B7-H3 with blocking mAbs; (B) Targeting B7-H3 through ADCC; (C) Targeting B7-H3 through ADC therapies; (D) Targeting B7-H3 with CD3-engaging BsAbs; (E) BiKEs and TriKEs; (F) Targeting B7-H3 with small-molecule inhibitors; (G) Targeting B7-H3 with CAR T cells and CAR-NK cells; (H) Synergistic options with anti B7-H3 therapies.