Table 4.
Logistic regression analysis of the factors associated with T790M positivity.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value |
| Age ⩾65 years | 0.92 (0.52–1.64) | 0.782 | – | – |
| Male | 0.84 (0.47–1.50) | 0.565 | – | – |
| ECOG PS 0–1 | 0.66 (0.27–1.56) | 0.361 | – | – |
| Current/ex-smoker | 0.86 (0.46–1.63) | 0.646 | – | – |
| EGFR exon 19del | 1.56 (0.88–2.79) | 0.132 | 1.62 (0.85–3.10) | 0.145 |
| Brain metastasis | 2.10 (1.15–3.91) | 0.018 | 2.12 (1.08–4.26) | 0.030 |
| Liver metastasis | 1.52 (0.65–3.77) | 0.348 | – | – |
| Afatinib treatment | 0.33 (0.18–0.61) | <0.001 | 0.27 (0.14–0.53) | <0.001 |
| PFS ⩾12 months | 1.99 (1.12–3.58) | 0.019 | 3.00 (1.56–5.98) | 0.001 |
CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; PFS, progression-free survival.