Table 1.
Clinical and Demographic Variables for Patients and Controls.a
| lvPPA-only (n = 9) | PPA (n = 12) | bvFTD (n = 12) | AD (n = 28) | Control (n = 20) | F/χ2 value | P value | |
|---|---|---|---|---|---|---|---|
| Age, mean (SD) | 62.8 (7.5) | 63.2 (6.7) | 61.0 (11.9) | 62.5 (5.6) | 64.9 (9.6) | F = 0.603 | n.s. |
| Gender (male/female) | 6/3 | 7/5 | 8/4 | 16/12 | 12/8 | χ2 = 0.328 | n.s. |
| Years of education, mean (SD) | 17.0 (4.8)b | 15.6 (4.7)c | 12.2 (3.7)c | 13.4 (3.0)d | 14.7 (2.7) | F = 2.451 | n.s. |
| AES, mean (SD)/72 | 42.2 (13.1) | 41.3 (12.1) | 55.3 (9.5) | 42.9 (9.3) | 27.7 (5.9) | F = 24.828 | <.001 |
| GDS-15, mean (SD)/15 | 11.7 (5.4) | 5.9 (5.5) | 5.0 (2.3 | 6.5 (4.3) | 1.9 (2.0) | F = 6.524 | <.001 |
| Age onset, mean (SD) | 61.0 (6.0)e | 58.3 (6.9)f | 52.1 (11.9)g | 57.9 (6.3)h | F = 2.035 | n.s. | |
| Disease duration, median (IQR) | 4 (1.5)e | 5 (1.75)f | 5 (7)g | 5 (4)h | F = 2.102 | n.s. | |
| ACE-III total, mean (SD)/100 | 62.9 (26.0) | 66.3 (24.2)i | 71.4 (14.5)c | 65.2 (15.8) | F = 0.472 | n.s. | |
| ECAS cognitive total, mean (SD)/136 | 61.8 (35.9) | 67.2 (34.9) | 72.3 (22.0)g | 72.5 (21.1)j | F = 0.157 | n.s. | |
| ECAS behavior domain, median (IQR)/5 | 3 (3) | 2 (3.5)c | 5 (3)g | 2 (1.5)j | F = 6.305 | <.01 | |
| LIADL total, mean (SD)/8 | 6.1 (1.4) | 6.5 (1.4) | 3.2 (1.5) | 5.1 (2.0) | F = 10.949 | <.001 |
Abbreviations: ACE-III, Addenbrooke’s Cognitive Examination III; AD, Alzheimer’s disease; AES, Apathy Evaluation Scale; bvFTD, behavioral variant frontotemporal dementia; ECAS, Edinburgh Cognitive and Behavioural ALS Screen; GDS-15, Geriatric Depression Scale–Short Form; IQR, interquartile range; LIADL, Lawton Instrumental Activities of Daily Living; lvPPA, logopenic variant primary progressive aphasia; n.s., not significant; PPA, primary progressive aphasia.
a Comparison is between PPA, bvFTD, AD, and controls. The lvPPA-only group is a subsample from the PPA group.
b n = 8.
c n = 11.
d n = 22.
e n = 7.
f n=10.
g n = 9.
h n = 27.
i n = 12.
j n = 15.