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. 2021 Jul 19;12:713294. doi: 10.3389/fimmu.2021.713294

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Copyright © 2021 Cheng, He, Gao, Zhao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustrations of the structure and main function of ZBTB protein domains. The N-terminal BTB domain mainly mediates the protein-protein interactions, while the C-terminal ZFs mainly mediate the bindings to DNA. The ZF domains may interact with other TFs or proteins as well. The linker domain is unstructured, often flexible and targeted for posttranslational modifications (A). (B) functional domains of the fourteen ZBTB proteins discussed in this review. PATZ1 and ZBTB24 contain an additional A-T hook domain with DNA-binding ability.