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. 2021 Jul 19;12:707344. doi: 10.3389/fphys.2021.707344

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Copyright © 2021 Zou, Zhou, Xi, Huang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological evaluation of the renal tissue at 24 h after renal IRI. (A) Representative photographs of kidney sections stained with hematoxylin and eosin (original magnification 200×). (B) Histological scoring of the kidney sections. Arrows indicate tubular dilatation, swelling, congestion, vacuolization, and tubular necrosis in the kidneys (n = 4). Compared to the sham group, ^∗∗∗ represents p < 0.001; compared to the IRI group, ### represents p < 0.001; compared to the Pio + IRI group, +++ represents p < 0.001.