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Model of MPDZ function at the hair cell apical surface. Unlike GNAI-GPSM2 restricted to the bare zone (hatched), the Crumbs complex at the apical membrane (CRB3-MPP5-MPDZ, magenta) is also detected on the medial side of the hair bundle, although at lower levels. In the absence of MPDZ (and thus CRB3-MPP5), the GNAI-GPSM2 versus aPKC (dotted) blueprint is not maintained from P4, and stereocilia placement is defective.
