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. 2021 Jul 19;15:701355. doi: 10.3389/fnins.2021.701355

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Copyright © 2021 Gong, Huang, Yang, Chen, Pu, He and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and pathway analysis of differential fecal metabolites between the control and CSDS mice. (A) 20 fecal metabolites were identified to be significantly changed in the CSDS mice. Compared to the control mice, only one metabolite (hydroxybenzoic acid) was significantly decreased, whereas the other 19 metabolites were increased in the CSDS mice. (B) Pathway analysis for fecal metabolites based on KEGG database revealed that 13 pathways were disturbed in the CSDS mice, of which most (4/13) were involved in lipid metabolism. CON, mice in the control group; CSDS, mice in the CSDS group.