Table I.
Bacteriocins with potential application as therapeutic and food preservatives.
| Bacteriocin | Producer bacteria | Target microorganism | Use | Reference |
|---|---|---|---|---|
| 1. Food preservation | ||||
| AMA-K, Leucocin K7 | L. plantarum AMA-K |
Enterococcus spp., E. coli, K. pneumoniae, Listeria spp. |
Amasi, fermented milk product | (Todorov 2008) |
| Aureocin A70 | S. aureus A70 | L. monocytogenes | Dairy product | (Carlin Fagundes et al. 2016) |
| Bacteriocin 32Y | L. curvatus | L. monocytogenes | Pork and beef | (Gálvez et al. 2007) |
| Bacteriocin GP1 | L. rhamnosus GP1 |
Staphylococcus sp., Aeromonas sp., Lactobacillus sp., Pseudomonas sp., Vibrio sp. |
Fish | (Sarika et al. 2019) |
| Bovicin HC5 + Nisin | Streptococcus bovis HC5 | L. monocytogenes, S. aureus | Fresh cheese | (Pimentel-Filho et al. 2014) |
| Divergicin M35 | Carnobacterium divergens M35 | L. monocytogenes | Smoked fish | (Benabbou et al. 2020) |
| Enterocin | E. faecium FAIR-E 198 | Listeria spp. | Feta cheese | (Sarantinopoulos et al. 2002) |
| Enterocin 416K1 | E. casseliflavus IM 416K1 | L. monocytogenes NCTC 10888 | Cottage cheese | (Iseppi et al. 2008) |
| Enterocin AS-48 | Enterococcus sp. | L. monocytogenes, B. cereus | Cheese, vegetable, purees, and soups | (Gálvez et al. 2007) |
| H1, H2, H3, H4 | Bacillus sp. | V. alginolyticus, Aeromonas hydrophilla, P. stutzeri | Antimicrobial used in fish | (Feliatra et al. 2018) |
| Lacticin 3147 | L. lactis | L. monocytogenes | Matured and cottage cheese | (Mills et al. 2017) |
| Lacticin NK24 | L. lactis |
Leuconostoc mesenteroides KCCM 11324 |
Seafood | (Lee and Paik 2001) |
| Leucocin K7 | L. mesenteroides K7 | L. monocytogenes | Dairy product | (Shi et al. 2016) |
| Mecedocin |
S.
macedonicus ACA-DC 198 |
C. tyrobutyricum LMG 1285T | Kasseri cheese | (Anastasiou et al. 2009) |
| NE |
L.
gasseri K7 (Rifr), L. gasseri LF221(Rifr) |
C. tyrobutyricum | Semi-mature cheese | (Bogovič Matijašić et al. 2007) |
| Nisin |
Lactococcus spp., Streptococcus spp. |
L. monocytogenes, Clostridium botulinum, S. mutans, L. innocua, S. aureus, S. pneumoniae, B. cereus |
Dairy products, meat, seafood | (Juturu and Wu 2018) |
| Pediocin PA1 | P. acidilactici | L. monocytogenes | Dairy products, meat | (Liu et al. 2008) |
| Plant-made salmocins | Salmonella spp. | S. enterica | Red meat | (Schneider et al. 2018) |
| Plant-made colicins (GRN 676, GRN 593) | E. coli |
E. coli, P. aeruginosa, Salmonella spp. |
Meat, fruits, or vegetables | (Hahn-Löbmann et al. 2019) |
| Psicolin 126, carnocyclin A | C. maltoaromaticum | L. monocytogenes | Ready-to-eat meat products | (Liu et al. 2014) |
| Reuterin | L. reuteri |
E.
coli, S. aureus, Candida albicans |
Food preservation | (Helal et al. 2016) |
| Sakacin P | L. sakei | L. monocytogenes | Beef and Salmon | (Teneva-Angelova et al. 2018) |
| Thuricin BtCspB | B. thuringiensis | B. cereus | Food preservation and disease associate to B. cereus | (Huang et al. 2016) |
| 2. Bacterial infections | ||||
| ABP118 | L. salivarius subsp. salivarius UCC118 | Bacteroides | Antimicrobial agent | (Riboulet-Bisson et al. 2012) |
| Colicins Js and Z | E. coli | Enteroinvasive, E. coli (EIEC) and Shigella | Gastrointestinal infections | Bosák et al. 2021 |
| Divercin V41 | C. divergens | L. monocytogenes | Antimicrobial agent | (Rihakova et al. 2010) |
| Duramycin | Streptomyces cinnamoneus | B. subtilis | Antimicrobial, anti-viral, immunomodulation, ion channel modulation, treatment of atherosclerosis and cystic fibrosis | (Huo et al. 2017) |
| Enterocin CRL35 | E. mundtii | L. monocytogenes | Gastrointestinal infections | (Salvucci et al. 2012) |
| Epidermin and mersacidin-like peptides | S. epidermidis | P. acnes | Acne, folliculitis. | (Gillor et al. 2008) |
| Gallidermin/epidermin | S. gallinarum | S. epidermidis, S. aureus | Skin infections or associated with implants and prostheses | (Bengtsson et al. 2018; Bonelli et al. 2006) |
| Gassericin E | L. gasseri EV1461 | Pathogens associated with vaginosis | Vaginal infections | (Maldonado-Barragán et al. 2016) |
| Haemocin type B |
Haemophilus haemolyticus |
H. influenza | Respiratory infections | (Latham et al. 2017) |
| Lactocin 160 | L. rhamnosus | G. vaginalis | Urogenital tract infections, bacterial vaginosis | (Turovskiy et al. 2009) |
| Laterosporulin10 | Brevibacillus sp. strain SKDU10 |
S. aureus, Mycobacterium tuberculosis (Mtb H37Rv), M. smegmatis MC2 155 |
Human microbial pathogens | (Baindara et al. 2016) |
| Mersacidin | B. amyloliquefaciens | Methicillin-resistant S. aureus (MRSA) |
Skin infection | (Kruszewska et al. 2004) |
| Microcin J25 (lasso-peptide) | E. coli | S. enterica, E. coli, S. flexnerii | Gastrointestinal infections | (Dobson et al. 2012) |
| Nisin A, Nisin Z, Nisaplin | L. lactis |
S.
mutans, S.
aureus, E.
faecalis, S. mastitis, C. albicans |
Gastrointestinal, respiratory, and skin infections, oral health | (Shin et al. 2016) |
| Oralpeace TM (encapsulated nisin) | L. lactis | S. mutans, P. gingivalis | Dental caries, gingivitis | (Perez et al. 2014) |
| Piscicolin 126 | Carnobacterium spp. | Listeria spp. | Antimicrobial agent | (Miller and McMullen 2014) |
| Plantaricin 423 | L. plantarum | Listeria spp. | Antimicrobial agent | (Guralp et al. 2013) |
| PLNC8 αβ | L. plantarum |
Staphylococcus sp., Porphyromonas gingivalis |
Antimicrobial agent | (Bengtsson et al. 2020) |
| R-pyocins | P. aeruginosa | P. aeruginosa | Antimicrobial agent | (Redero et al. 2018) |
| TOMM Streptolysin S (SLS) | S. pyogenes |
Clostridium sp., Listeria sp. |
Hemolytic and cytotoxic activity against macrophages and neutrophils | (Molloy et al. 2015) |
| 3. Anticancer drugs | ||||
| Cancer cell lines | ||||
| Azurin | P. aeruginosa | MCF-7, UISO-Mel-2, osteosarcoma (U2OS) | (Nguyen and Nguyen 2016) | |
| Bovicin HC5 | S. bovis HC5 | MCF-7, HepG2 | (Rodrigues et al. 2019) | |
| Colicin E3 | E. coli | P388, HeLa, HS913T | (Kohoutova et al. 2014 | |
| Duramycin | S. cinnamoneus | AsPC-1, Caco-2, Colo320, CT116, JJN3, Lovo, MCF-7, MDA-B-231, MIA PaCa-2 | (Rodrigues et al. 2019) | |
| Enterocin LNS18 | E. thailandicus | HepG2 | (Al-Madboly et al. 2020) | |
| Laterosporulin LS10 | Brevibacillus laterosporus SKDU10 | HeLa, MCF-7, H1299, HEK293T, HT1080 | (Baindara et al. 2016) | |
| sporus SKDU10 | ||||
| M2163, M2386 | L. casei ATCC 334 | SW480 | (Rodrigues et al. 2019) | |
| Microcin E492 | K. pneumoniae | HeLa, Burkitt lymphoma variant (RJ2.25) | (Kaur and Kaur 2015) | |
| Nisin A | L. lactis | Head and neck squamous cell carcinoma (HNSCC) | (Shin et al. 2016) | |
| Pediocin K2a2-3 | P. acidilactici K2a2-3 | HT2a, HeLa | (Villarante et al. 2011) | |
| Pediocin CP2 | P. acidilactici CP2 MTCC501 | HeLa, MCF-7, HepG2, murine myeloma (Sp2/0-Ag 14) | (Kumar et al. 2012) | |
| Pep27anal2 | S. pneumoniae | Jurkat, HL-60, AML-2, MCF-7, SNU-601 | (Rodrigues et al. 2019) | |
| Plantaricin A | L. plantarum C11 | GH4, Reh, Jurkat, PC12, N2A | (Sand et al. 2013) | |
| Plantaricin P1053 | L. plantarum PBS067 | E705 | (De Giani et al. 2019) | |
| Pyocin S2 | P. aeruginosa 42A | HepG2, Im9, murine tumor (mKS-A TU-7), human fetal foreskin fibroblast (HFFF) | (Abdi-Ali et al. 2004) | |
| Sungsanpin | Streptomyces spp. | A549 | (Um et al. 2013) | |
| Smegmatocin | M. smegmatis 14468 | HeLa, AS-II, HGC-27, mKS-A TU-7 | (Kaur and Kaur 2015) | |
NE – non specified