Table 1.
The Role of miRNA With Signal Pathway Regulation in the CDDP Resistance of OS.
| miRNA | Expression level in OS | Gene target | Signal pathway | Effect after intervention | References |
|---|---|---|---|---|---|
| miRNA-33a | ↑ | TWIST | PI3K/Akt, ET-1/ETAR | Increased chemotherapy sensitivity of CDDP | 11 |
| miRNA-221 | ↑ | PTEN | PI3K/Akt | Reduced CDDP resistance | 17 |
| miRNA-100 | ↓ | IGFIR | PI3K/Akt, MAPK/Erk | Reduced CDDP resistance | 18 |
| miRNA-34a | ↓ | – | c-Myc/Bim | Increased chemotherapy sensitivity of CDDP | 19 |
| miRNA-223 | ↓ | Hsp70 | JNK/JUN | Increased chemotherapy sensitivity of CDDP | 20 |
| miRNA-22 | ↓ | MTDH | LC3/ATG5/Beclin1 | Increased chemotherapy sensitivity of CDDP | 22 |