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. 2021 Jul 19;12:707713. doi: 10.3389/fgene.2021.707713

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Copyright © 2021 Jin, Li, Hao, Tang, Wang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selection of the key module and visualization of the topological overlap matrix (TOM). (A) Module–trait relationships among the eight gene modules. (B) Gene significance (GS) across modules. The GS value of the yellow module was the highest. (C) Module membership (MM) vs. GS in the yellow module. The red dotted lines represent the thresholds of MM > 0.9 and GS > 0.3 set for interesting genes. (D) Heatmap showing the TOM among all 5,000 genes involved in the WGCNA. (E) Eigengene dendrogram and adjacency heatmap further clarify the correlation between intracerebral hemorrhage (ICH) and the modules.