TABLE 4.

Enriched functional terms and their enrichment scores following DAVID analysis for genes identified by all methodologies in the SD_G1 (AL) Sudanese sheep group.

Group	Type	Category	TermGene count	P value	Genes	Benjamini
SD_G1 vs. SD_G2 (334 annotated genes)	GOTERM_BP_DIRECT	GO:0009952	Anterior/posterior pattern specification10	0.00001	HOXC5, HOXC4, HOXC9, GRSF1, HOXC8, HOXC11, GLI3, HOXC10, ACVR2A, HOXC6	0.00933
	GOTERM_MF_DIRECT	GO:0004861	Cyclin-dependent protein serine/threonine kinase inhibitor activity4	0.00042	CDKN2D, KAT2B, CDKN2C, INCA1	0.08136
	GOTERM_CC_DIRECT	GO:0005737	Cytoplasm58	0.00052	SLC23A2, STAB2, SRA1, HOXC11, EFTUD2, EPB41L4B, PPP2R5E, SESN1, MMP28, MEIOC, ARIH1, TRIM21, PDGFRA, PARP4, ARID1B, GLTPD2, RNF167, NEIL2, RUFY3, SLFN14, PICK1, CACTIN, DTL, ARF5, GTSF1, ATG4D, GTF2A1, ITIH4, UBA6, SRF, PRICKLE2, DBF4B, PLA2G6, RPAP2, CENPC, EPB41L5, ORC4, STK36, PSMB1, STXBP5, APBB3, HOXC6, CDKN2D, KLHDC3, RRM1, ZFHX3, TGFB1, PPIL2, CDKN2C, STAT1, SNCAIP, ACVR2A, COPS2, NF1, TPP2, PDCD2, PTPN4, MPHOSPH8	0.10205
	KEGG_PATHWAY	oas05152	Tuberculosis10	0.00244	TGFB1, SC5, STAT1, IFNGR1, CATHL3, AKT3, MAPK1, CD14, FADD, BAC5	0.27089
	GOTERM_MF_DIRECT	GO:0043022	Ribosome binding5	0.00255	LETM1, SPCS1, EFL1, SLFN14, RICTOR	0.24848
	KEGG_PATHWAY	oas05212	Pancreatic cancer6	0.00279	RALB, TGFB1, STAT1, AKT3, TGFA, MAPK1	0.27089
	GOTERM_BP_DIRECT	GO:0030212	Hyaluronan metabolic process3	0.00407	ITIH4, ITIH3, ITIH1	1.00000
	GOTERM_CC_DIRECT	GO:0005730	Nucleolus19	0.00507	ZFHX3, WDR36, IK, CBX5, RNMT, UTP3, STAT1, NAT10, KRI1, RPAP2, GNL3, ORC4, EXOSC5, NOVA1, CAMK4, TRIM68, NOL10, DTL, MPHOSPH8	0.49461
	GOTERM_MF_DIRECT	GO:0008289	Lipid binding6	0.00607	BPIFA1, STARD4, BPIFB1, FABP5, BPIFA3, FABP12	0.39428
	GOTERM_BP_DIRECT	GO:0019985	Translesion synthesis3	0.00832	POLN, SPRTN, DTL	1.00000
SD_G1 vs. CN_G1 (224 annotated genes)	GOTERM_BP_DIRECT	GO:0045921	Positive regulation of exocytosis3	0.01215	CADPS2, VSNL1, CFTR	1.00000
	GOTERM_CC_DIRECT	GO:0005922	Connexon complex3	0.01325	GJB2, GJA3, GJB6	1.00000
	GOTERM_MF_DIRECT	GO:0030345	Structural constituent of tooth enamel2	0.02370	ENAM, AMBN	1.00000
	GOTERM_BP_DIRECT	GO:0070175	Positive regulation of enamel mineralization2	0.02610	ENAM, AMTN	1.00000
	GOTERM_CC_DIRECT	GO:0005730	Nucleolus12	0.02915	RSL1D1, ZFHX3, WDR36, IK, PSPC1, CAMK4, ATXN1L, CRYL1, NOL10, SNRPB2, RPAP2, MPHOSPH8	1.00000
SD_G1 vs. CN_G2 (365 annotated genes)	GOTERM_CC_DIRECT	GO:0005737	Cytoplasm60	0.00031	GMEB2, BICDL1, SRA1, STMN3, MSI1, HOXC11, XPO4, SIN3A, SESN1, RNF17, ARIH1, AZI2, KPNA1, PARP4, DTX3L, MYT1, ARID1B, COMMD4, ASPM, LATS2, TIPRL, ZNF438, PICK1, TLN1, NEIL1, ACTL7B, PXN, TUBD1, PLA2G6, RPAP2, LIMA1, PSMB7, NUAK1, STK36, DND1, APBB3, GCN1, SCAI, HOXC6, GINS1, PTPN18, ACD, ZFHX3, SRMS, SPAG8, NEK6, PTK6, PARP14, PTPN14, MSMP, GDF9, CENPF, CDAN1, MYBBP1A, COPS2, NF1, PTPN9, MPHOSPH8, EEF1AKMT1, CDK5R2	0.06403
	GOTERM_BP_DIRECT	GO:0009952	Anterior/posterior pattern specification8	0.00050	HOXC5, HOXC4, HOXC9, HOXC8, HOXC11, GLI3, HOXC10, HOXC6	0.37470
	GOTERM_MF_DIRECT	GO:0003950	NAD+ ADP-ribosyltransferase activity4	0.00244	PARP4, SIRT4, PARP9, PARP14	0.44686
	GOTERM_BP_DIRECT	GO:0007194	Negative regulation of adenylate cyclase activity3	0.00839	P2RY13, GPR87, DRD3	1.00000
	GOTERM_MF_DIRECT	GO:0043565	Sequence-specific DNA binding11	0.01275	NR5A1, NFE2, ZFHX3, ZGPAT, LHX2, FEV, HOXC5, HOXC4, HOXC9, HOXC8, HOXC6	0.87513
	GOTERM_BP_DIRECT	GO:0019731	Antibacterial humoral response3	0.01400	PLA2G1B, PLA2G6, JCHAIN	1.00000
	GOTERM_MF_DIRECT	GO:0043022	Ribosome binding4	0.01621	LETM1, HSPA5, EFL1, GCN1	0.87513
	GOTERM_CC_DIRECT	GO:0008180	COP9 signalosome4	0.01830	STOML2, HSPA5, COPS2, DOCK7	0.97140
	KEGG_PATHWAY	oas04721	Synaptic vesicle cycle4	0.04776	ATP6V1G1, CLTC, ATP6V0D1, CPLX1	1.00000