Table 1.
Animal characteristics of the three experimental groups.
| Control(n = 7) |
UCO Animals |
|||
|---|---|---|---|---|
| UCO + Not Treated(n = 11) | UCO + TH/Epo(n = 11) | P-valued | ||
| Demographics: | ||||
| Female – n (%) | 4 (57.1%) | 3 (27.3%) | 8 (72.3%) | 0.03 |
| Birthweight (g) – median (IQR) | 558 (5,09,599) | 625 (5,39,631) | 526 (4,95,586) | 0.25 |
| Days delivered early – median (IQR) | 3.0 (3.0, 4.5) | 4.0 (3.5, 5.0) | 4.0 (3.0, 4.0) | 0.37 |
| UCO (min) – median (range) | 0 (0–9) | 20 (8–20) | 20 (18–20) | 0.46 |
| Clinical parameters: | ||||
| Time to intubation (min) – median (range) | – | 6 (0–13) | 2.3 (0–10) | 0.77 |
| Apgar at 10 min – median (IQR) | 9 (8.0, 9.0) | 3 (2.5, 6.0) | 3 (2.5, 3.0) | 0.38 |
| pH – median (IQR) | 7.32 (7.26, 7.34) | 7.08 (7.01, 7.13) | 7.10 (7.06, 7.18) | 0.61 |
| Base deficit (mEq/L) – median (IQR) | –2.6 (–6.0, 1.0) | –15.1 (–18.2, –12.4) | –16.5 (–19.5, –14.5) | 0.32 |
| Lactate (mmol/L) – median (IQR)a | 1.4 (1.1, 2.0) | 10.5 (9.3, 13.3) | 11.1 (9.7, 12.3) | 0.30 |
| pCO2 (mmHg) – median (IQR)b | 43.4 (39.0, 50.4) | 44.5 (39.6, 45.7) | 39.9 (33.9, 50.8) | 0.44 |
| Moderate or severe injury – n (%)c | 0 (0%) | 8 (72.3%) | 10 (90.1%) | 0.29 |
aThere was 1 animal with missing data on lactate, and 1 animal with measure “>20” which was conservatively assumed to be 20.1.
bThere was 1 animal with missing data on pCO2.
cDerivation and classification of injury score was based on pH, base deficit, and apgar score at 10 min. Animals with a score of 3 were assigned to the normal/mild group, with animals scoring >3 assigned to the moderate/severe group.
dP-values were included from two-sample t-tests to assess the differences in baseline characteristics between between UCO + TH/Epo animals and UCO + Not Treated aninmals.