Table 2.
BPND0 in PD patients and age-matched controls and the relative change in BPND (%).
| VOI | BPND0 |
ΔBPND(%) |
|||||
|---|---|---|---|---|---|---|---|
| PD (n = 13) | HC (n = 10) | p-value | PD (n = 13) | p-value | HC (n = 10) | P-value | |
| FC | 0.85 ± 0.17 | 1.12 ± 0.27 | .01 * | −5 ± 11 | .08 | 6 ± 12 | .12 |
| TC | 0.79 ± 0.15 | 0.95 ± 0.25 | .09 | −11 ± 9 | .002** | 3 ± 11 | .21 |
| PC | 0.79 ± 0.13 | 1.00 ± 0.21 | .01 * | −2 ± 11 | .33 | 12 ± 12 | .02 |
| LC | 1.02 ± 0.21 | 1.28 ± 0.34 | .05 | −9 ± 12 | .01* | 2 ± 7 | .17 |
| OC | 1.06 ± 0.16 | 1.16 ± 0.22 | .26 | −8 ± 9 | .02* | 0 ± 8 | .74 |
| Post-hoc analyses | |||||||
| Neo | 0.84 ± 0.14 | 1.05 ± 0.24 | .02 | −7 ± 10 | .03 | 6 ± 10 | ns |
| SFG | 0.80 ± 0.20 | 1.07 ± 0.25 | .01 | −6 ± 12 | ns | 5 ± 13 | ns |
| PMC | 0.86 ± 0.19 | 1.11 ± 0.27 | .02 | −6 ± 16 | ns | 7 ± 14 | ns |
| dlPFC | 0.75 ± 0.22 | 1.12 ± 0.31 | .005 | −2 ± 20 | ns | 8 ± 14 | ns |
| vlPFC | 1.02 ± 0.19 | 1.26 ± 0.32 | .05 | −2 ± 11 | ns | 9 ± 12 | .04 |
| MIFG | 0.90 ± 0.18 | 1.19 ± 0.29 | .01 | −2 ± 12 | ns | 8 ± 12 | ns |
| OFG | 0.86 ± 0.19 | 1.00 ± 0.27 | ns | −11 ± 14 | .03 | 4 ± 19 | ns |
| STG | 0.79 ± 0.18 | 0.97 ± 0.31 | ns | −15 ± 10 | .002 | 4 ± 12 | ns |
| MITG | 0.80 ± 0.14 | 0.94 ± 0.22 | ns | −6 ± 8 | .02 | 2 ± 10 | ns |
| SSC | 0.73 ± 0.19 | 1.00 ± 0.24 | .01 | −5 ± 15 | ns | 8 ± 12 | ns |
| ACC | 1.09 ± 0.23 | 1.38 ± 0.33 | .03 | −7 ± 10 | .04 | 2 ± 11 | ns |
| PCC | 0.88 ± 0.19 | 0.89 ± 0.21 | ns | −17 ± 15 | ns | −5 ± 11 | ns |
| Ins | 0.99 ± 0.21 | 1.23 ± 0.36 | ns | −11 ± 13 | .02 | 1 ± 6 | ns |
| Cau | 0.66 ± 0.28 | 1.07 ± 0.37 | .006 | 2 ± 29 | ns | 8 ± 21 | ns |
| Put | 1.25 ± 0.25 | 1.42 ± 0.46 | ns | 4 ± 12 | ns | 20 ± 13 | .004 |
| Tha | 0.49 ± 0.12 | 0.55 ± 0.14 | ns | −16 ± 21 | ns | −3 ± 14 | ns |
Abbreviations: frontal cortex (FC), parietal cortex (PC), temporal cortex (TC), occipital cortex (OC), limbic cortex (LC), neocortex (Neo), superior frontal gyrus (SFG), primary motor cortex (PMC), dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), medial inferior frontal gyrus (MIFG), orbitofrontal gyrus (OFG), superior temporal gyrus (STG), medial inferior temporal gyrus (MITG), somatosensory cortex (SSC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), insular cortex (Ins), caudate (Cau), putamen (Put) and thalamus (Tha). For primary VOI’s, the given p-values are uncorrected for multiple corrections; those p-values that survive the Bonferoni-Holm correction, are marked with an Asterix (*).