Cortical gyri perfusion and structure in chronic TBI. CVR is decreased in temporal grey matter of the brains of chronic TBI subjects. T1-weighted MRI analysis showed no statistically significant differences in thickness (a and b, t test, p > 0.05) or resting CBF (c and d, t test, p > 0.05) values of the cortical gyri of the multiple cortical sub-regions of either the left or right hemisphere between TBI patients and HC subjects. There was a statistically significant decrease in CVR values of the inferior- and superior-temporal cortical gyri of the left hemisphere of TBI patients, with respect to HC participants (e, unpaired t test, p < 0.05), and a decrease in CVR values of the inferior-, middle-, and superior-temporal cortical gyri of the right hemisphere of TBI patients, compared to that of HC subjects (f, unpaired student t test, p < 0.05). No statistical significance between groups unless otherwise stated. Error bars represent ± SD. HC, n = 14; TBI, n = 27. *p < 0.05.