Figure 6.

Comparison of the proportion of imaging abnormalities between TBI and HC subjects across multiple brain ROIs using separate modalities. Chronic TBI patients have more abnormal ROIs than HC subjects in all imaging modalities studied. Each brain was segmented into 96 ROIs and the mean MD, FA, CVR, and CBF in each ROI was measured. Mean values were converted to z-scores based on the pool of healthy controls. Number of abnormal ROIs with a MD > 2.5 z-score (a) or FA, CVR, and CBF < −2.5 z-score (b–d) were tallied. TBI subjects had more abnormal ROIs in both structural and vascular modalities. HC, n = 14; TBI, n = 27.