Fig. 5.

Schematic illustration of the contribution of MCTS1 to EMT, tumor escape from immune surveillance, and activation of pro-inflammatory factors by tumor cells. EMT – epithelial-mesenchymal transition; Snail and Slug – transcription factors involved in EMT; EGFR – epidermal growth factor receptor; pro-inflammatory cytokines IL-6 – interleukin-6, MCP-1 – monocyte chemoattractant protein, and GM–CSF – granulocyte-macrophage colony-stimulating factor; M1 – classically activated macrophages providing the production of pro-inflammatory cytokines; M2 – macrophages responsible for anti-inflammatory response