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Enhancing AdipoRon water solubility improves pharmacokinetics and bioavailability. A: Chemical structures of AdipoRon and AdipoRonPEG5 and their predicted LogP values. B: Images of AdipoRon and AdipoRonPEG5 aqueous solutions (both 1.2 mM) with additives. C: Quantification of water solubilities by LC-MS/MS. D and E: Pharmacokinetic profiles of AdipoRon and AdipoRonPEG5 in the plasma (D) or liver (E) upon IP dosing at 20 mg/kg in 8-week-old C57BL/6J mice (N = 3, Mean ± SEM).
