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Pharmacological improvements of AdipoRonPEG5 enhance its action through AdipoR to exert pleiotropic benefits on metabolism, cell function, and survival. The cellular signaling and physiological outcomes of AdipoRonPEG5 and AdipoRon are shown in blue and red, respectively. Signaling pathways or biological functions common to both drugs are shown in black. The scheme mainly includes results from the current study for clarity.
