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. 2021 Jul 19;12:691590. doi: 10.3389/fimmu.2021.691590

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Copyright © 2021 Wei, Xue, Lan, Yuan, Li, Guo, Zhang, Ding and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arctigenin relieves the symptoms of EAE. (A) Arctigenin was intraperitoneally injected everyday (10 mg/kg) at the beginning after EAE induction. The mean of the daily clinical scores recorded from day 1 to day 30 post-induction after treatment with 10 mg/kg Arctigenin. (B) The mean of the total of the daily clinical scores observed between day 1 and day 30. (C) The maximum clinical score of individual mice between day 1 and day 30. All data are expressed as mean ± SEM, n=6 mice per group, **p < 0.01, one-way ANOVA with Kruskal-Wallis test.