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. 2021 Jul 19;12:699253. doi: 10.3389/fphys.2021.699253

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Copyright © 2021 Hartmann, Lang, Zeng, Duan, Zhang, Wang, Bondareva, Kruglov, Fouts, Stärkel and Schnabl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AUD Patients with progressive liver disease have higher abundance of Malassezia than AUD patients with non-progressive liver disease. (A) PCoA of mycobiome in AUD patients with progressive liver disease (n = 37) and AUD patients with non-progressive liver disease (n = 29). (B) LDA of fungal subpopulations of AUD patients with progressive versus non-progressive liver disease. (C–F) Relative abundance of genera (C) Malassezia, (D) Candida, and of species (E) Candida albicans, and (F) Candida zeylanoides. A P value of equal or less than 0.05 was considered as statistically significant. AUD, alcohol use disorder; LDA, linear discriminant analysis; PCoA, principal coordinate analysis.