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. 2021 Jul 19;9:708754. doi: 10.3389/fcell.2021.708754

TABLE 1.

Proteins involved in enzymatic activities.

Protein family (gene name) EC Functional activity Localization
TLC domain (TLCD4*, TLCD3A) 2.3.1.- Ceramide synthesis, possibly involved in lipid trafficking, metabolism, or sensing ER, Nucleus
AB hydrolase superfamily, Lipase family (DAGLA, DAGLB) 3.1.1.- Hydrolase activity PM
Dual specificity phosphatase catalytic domain (TPTE, TPTE2) 3.1.3.- Phosphatase activity Golgi apparatus, ER
Metallophosphoesterase domain (TMPPE, TMEM62*) 3.1.-.- Hydrolase activity Nucleoplasm, Mitochondria
Emopamil-binding protein family (EBP, EBPL*) 5.3.3.- Cholesterol biosynthesis Lipoprotein internalization N.B: EBPL function is undetermined but not involved in cholesterol biosynthesis ER, PM, Vesicle, Vacuole
CH25H 1.14.-.- Catalyzes the formation of 25-hydroxycholesterol from cholesterol ER, Vacuole
ZDHHC4 2.3.1.- Protein-cysteine S-palmitoyltransferase activity, protein targeting to membrane Golgi apparatus, ER, Vacuole
AGPAT4 2.3.1.- Transferase activity, transferring acyl groups Golgi apparatus, ER, Nucleoli, Vesicles
RNFT1 2.3.2.- E3 ubiquitin-protein ligase ER, Nucleoli
SYVN1 2.3.2.- E3 ubiquitin-protein ligase ER, PM, Nucleoplasm, Vacuole
CDIPT 2.7.8.- CDP-diacylglycerol metabolic process PM, Nuclear membrane
TAOK2 2.7.11.- Serine/threonine-protein kinase CM, Nucleoli, Nucleoplasm
AIG1 3.1.-.- Hydrolase activity: Long-chain fatty acid catabolic process Golgi apparatus, ER
DOLPP1 3.6.1.- Hydrolyzes dolichyl pyrophosphate and monophosphate ER, Vesicle, Vacuole
HACD2 4.2.1.- Catalyzes reaction in long-chain fatty acids elongation cycle ER

Asterisk (*) indicates protein is involved in enzymatic activity or member of enzyme family, but does not have an Enzyme Commission (EC) identifier. Families with italic font indicates additional homologous proteins were identified but a different number of transmembrane regions predicted (i.e., more or less than 5TM regions). CM, cell membrane; ER, endoplasmic reticulum; PM, plasma membrane.