TABLE 1.
Protein family (gene name) | EC | Functional activity | Localization |
TLC domain (TLCD4*, TLCD3A) | 2.3.1.- | Ceramide synthesis, possibly involved in lipid trafficking, metabolism, or sensing | ER, Nucleus |
AB hydrolase superfamily, Lipase family (DAGLA, DAGLB) | 3.1.1.- | Hydrolase activity | PM |
Dual specificity phosphatase catalytic domain (TPTE, TPTE2) | 3.1.3.- | Phosphatase activity | Golgi apparatus, ER |
Metallophosphoesterase domain (TMPPE, TMEM62*) | 3.1.-.- | Hydrolase activity | Nucleoplasm, Mitochondria |
Emopamil-binding protein family (EBP, EBPL*) | 5.3.3.- | Cholesterol biosynthesis Lipoprotein internalization N.B: EBPL function is undetermined but not involved in cholesterol biosynthesis | ER, PM, Vesicle, Vacuole |
CH25H | 1.14.-.- | Catalyzes the formation of 25-hydroxycholesterol from cholesterol | ER, Vacuole |
ZDHHC4 | 2.3.1.- | Protein-cysteine S-palmitoyltransferase activity, protein targeting to membrane | Golgi apparatus, ER, Vacuole |
AGPAT4 | 2.3.1.- | Transferase activity, transferring acyl groups | Golgi apparatus, ER, Nucleoli, Vesicles |
RNFT1 | 2.3.2.- | E3 ubiquitin-protein ligase | ER, Nucleoli |
SYVN1 | 2.3.2.- | E3 ubiquitin-protein ligase | ER, PM, Nucleoplasm, Vacuole |
CDIPT | 2.7.8.- | CDP-diacylglycerol metabolic process | PM, Nuclear membrane |
TAOK2 | 2.7.11.- | Serine/threonine-protein kinase | CM, Nucleoli, Nucleoplasm |
AIG1 | 3.1.-.- | Hydrolase activity: Long-chain fatty acid catabolic process | Golgi apparatus, ER |
DOLPP1 | 3.6.1.- | Hydrolyzes dolichyl pyrophosphate and monophosphate | ER, Vesicle, Vacuole |
HACD2 | 4.2.1.- | Catalyzes reaction in long-chain fatty acids elongation cycle | ER |
Asterisk (*) indicates protein is involved in enzymatic activity or member of enzyme family, but does not have an Enzyme Commission (EC) identifier. Families with italic font indicates additional homologous proteins were identified but a different number of transmembrane regions predicted (i.e., more or less than 5TM regions). CM, cell membrane; ER, endoplasmic reticulum; PM, plasma membrane.