Table 2.
Response to NAC and Surgical Outcomes.
| Variable | NIPS | NSC | P |
|---|---|---|---|
| n (%) | n (%) | ||
| NAC cycle | 6.8 ± 2.0 | 6.6 ± 1.7 | 0.500 |
| Tumor response | 42 (100) | 44 (100) | 0.824 |
| CR | 3 (7.1) | 2 (4.5) | |
| PR | 19 (45.2) | 22 (50.0) | |
| SD | 16 (38.1) | 14 (31.8) | |
| PD | 4 (9.5) | 6 (13.6) | |
| RR (CR+PR) | 22 (52.4) | 24 (54.5) | 0.841 |
| DCR (CR+PR+SD) | 38 (90.5) | 38 (86.4) | 0.522 |
| Ascites response | 64 (100) | 65 (100) | <0.001 |
| Disappearance | 29 (45.3) | 7 (10.8) | |
| Decreased | 23 (35.9) | 29 (44.6) | |
| Stable | 8 (12.5) | 21 (32.3) | |
| Progression | 4 (6.3) | 8 (12.3) | |
| Cytology response | 71 (100) | 71 (100) | <0.001 |
| Negative | 52 (73.2) | 31 (43.7) | |
| Positive | 19 (26.8) | 40 (56.3) | |
| Conversion surgery | 71 (100) | 71 (100) | 0.012 |
| No | 31 (43.7) | 46 (64.8) | |
| Yes | 40 (56.3) | 25 (35.2) | |
| R0 resection | 71 (100) | 71 (100) | 0.039 |
| No | 37 (52.1) | 49 (69.0) | |
| Yes | 34 (47.9) | 22 (31.0) | |
| Complication | 40 (100) | 25 (100) | 0.425 |
| No | 29 (72.5) | 19 (76.0) | |
| Yes | 11 (27.5) | 6 (24.0) |
Abbreviations: NAC, neoadjuvant chemotherapy; NIPS, neoadjuvant intraperitoneal and systemic chemotherapy; NSC, neoadjuvant systemic chemotherapy; CR, complete response; PR, partial response; SD, stable disease; PD, progression disease; RR, response rate; DCR, disease control rate.