Table 3.
Grade 3/4 NAC-Related Adverse Events (n = 142).
| Event | NIPS | NSC | P |
|---|---|---|---|
| N = 71 (%) | N = 71 (%) | ||
| Overall toxicity | 52 (73.2) | 49 (69.0) | 0.579 |
| Related death | 0 (0) | 0 (0) | NA |
| Leukopenia | 27 (38.0) | 22 (31.0) | 0.377 |
| Neutropenia | 41 (57.7) | 38 (53.5) | 0.612 |
| Thrombocytopenia | 16 (22.5) | 20 (28.2) | 0.440 |
| Anorexia | 11 (15.5) | 15 (21.1) | 0.385 |
| Vomitting | 13 (18.3) | 16 (22.5) | 0.532 |
| Neurotoxicity | 19 (26.8) | 17 (23.9) | 0.700 |
| Diarrhea | 18 (25.4) | 8 (11.3) | 0.030 |
Abbreviations: NAC, neoadjuvant chemotherapy; NIPS, neoadjuvant intraperitoneal and systemic chemotherapy; NSC, neoadjuvant systemic chemotherapy; NA, not applicable.