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. 2021 Jul 19;12:686133. doi: 10.3389/fphar.2021.686133

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Copyright © 2021 Li, Ning, Wei, Huang, Lu, Pang, Wu, Zhou, Zhou, Luo and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical metabolites with significant changes in AH subgroup. Lines in blue () represent ZYP group while in red () represent placebo group. Contents of metabolites were assessed with t test between ZYP and placebo group. Contents of metabolites are shown in this figure, i.e., (A) sphinganine, (B) trihexosylceramide (d18:1/26:1), (C) glucosylceramide (d18:1/26:0), (D) PIP3(16:0/16:1), (E) PIP2(18:1/18:1), (F) tauroursodeoxycholic acid, (G) PG(18:1/18:1), (H) TG(22:0/20:5/18:1), (I) TG(22:4/20:4/18:4), (J) L-asparagine, (K) L-glutamic acid, (L) kynurenic acid, (M) 11-deoxycorticosterone, (N) melatonin glucuronide, (O) hydroxytyrosol. *p < 0.05 were regarded as statistically significant, compared with placebo group.

Inline graphic — Typical metabolites with significant changes in AH subgroup. Lines in blue () represent ZYP group while in red () represent placebo group. Contents of metabolites were assessed with t test between ZYP and placebo group. Contents of metabolites are shown in this figure, i.e., (A) sphinganine, (B) trihexosylceramide (d18:1/26:1), (C) glucosylceramide (d18:1/26:0), (D) PIP3(16:0/16:1), (E) PIP2(18:1/18:1), (F) tauroursodeoxycholic acid, (G) PG(18:1/18:1), (H) TG(22:0/20:5/18:1), (I) TG(22:4/20:4/18:4), (J) L-asparagine, (K) L-glutamic acid, (L) kynurenic acid, (M) 11-deoxycorticosterone, (N) melatonin glucuronide, (O) hydroxytyrosol. *p < 0.05 were regarded as statistically significant, compared with placebo group.