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. Author manuscript; available in PMC: 2021 Aug 2.
Published in final edited form as: Trends Immunol. 2020 May 5;41(7):572–585. doi: 10.1016/j.it.2020.04.007

Figure 5. Mechanism of Action to date for Speckled Protein 140 (SP140) for Immune Cell Identity and Function.

Figure 5.

Lineage-defining transcription factors (TFs) for mature macrophages (such as PU.1) drive SP140 transcription. SP140 in turn docks to repressed chromatin marked by H3K27me3 and maintains the silencing of lineage-inappropriate genes, such as HOX, OLIG, and FOX, for the preservation of cell identity and function.