Table 2.
Risk Factors for Late HCC Recurrence
| Variables (RFS) | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| aMAP Score | ||||||
| ≤64.2 | ||||||
| 64.3–68.6 | 2.757 | 1.615–4.705 | <0.001 | 2.537 | 1.463–4.398 | <0.001 |
| ≥68.7 | 9.691 | 5.792–16.213 | <0.001 | 6.193 | 3.512–10.922 | <0.001 |
| Max Size (cm) | ||||||
| ≤3.0 | 0.663 | 0.352–1.249 | 0.204 | NA | NA | NA |
| >3.0 | ||||||
| Number | ||||||
| Solitary | 1.806 | 0.957–3.411 | <0.001 | 2.874 | 1.822–4.535 | <0.001 |
| Multiple | ||||||
| Ablation sessions | ||||||
| 1 | 1.827 | 0.964–3.460 | 0.064 | 1.469 | 0.562–3.836 | 0.433 |
| 2 | ||||||
| Location | ||||||
| Favorable | 1.806 | 0.957–3.411 | 0.068 | 1.788 | 0.683–4.683 | 0.237 |
| Unfavorable | ||||||
| Etiology | ||||||
| HBV | NA | NA | NA | |||
| HCV | 1.320 | 0.636–2.741 | 0.456 | |||
| Alcoholic | 1.519 | 0.372–6.199 | 0.600 | |||
| Antiviral Therapy | ||||||
| No | 0.651 | 0.425–0.996 | 0.048 | 0.815 | 0.518–1.282 | 0.376 |
| Yes | ||||||
| Cirrhosis | ||||||
| No | 5.146 | 1.265–20.927 | 0.022 | 3.450 | 0.828–14.380 | 0.090 |
| Yes | ||||||
| Child-Pugh class | ||||||
| A | 0.536 | 0.074–3.856 | 0.535 | NA | NA | NA |
| B | ||||||
| AFP (ng/mL) | ||||||
| ≤400 | 0.664 | 0.289–1.526 | 0.335 | NA | NA | NA |
| >400 | ||||||
| ALB (g/L) | ||||||
| ≤35 | 1.697 | 0.688–4.188 | 0.251 | NA | NA | NA |
| >35 | ||||||
| AST (U/L) | ||||||
| ≤40 | 0.760 | 0.435–1.328 | 0.335 | NA | NA | NA |
| >40 | ||||||
| ALT (U/L) | ||||||
| ≤40 | 1.341 | 0.818–2.197 | 0.245 | NA | NA | NA |
| >40 | ||||||
| γ-GT (U/L) | ||||||
| ≤60 | 1.244 | 0.786–1.968 | 0.352 | NA | NA | NA |
| >60 | ||||||
Abbreviations: NA, not applicable; HBV, hepatitis B virus; HCV, hepatitis C virus; ALBI, albumin-bilirubin; AFP, alpha-fetoprotein; ALB, albumin; AST, aspartic transaminase; ALT, alanine aminotransferase; γ-GT, γ-glutamyl transpeptidase.