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. 2021 Jul 29;220(10):e202012144. doi: 10.1083/jcb.202012144

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© 2021 Farmer et al.

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Figure 5. — XMAP215 drives microtubule catastrophe by perturbing the growing microtubule end structure. (A) Microtubules polymerized with low tubulin grow slowly with small GTP-caps. Loss of GTP-tubulin triggers catastrophe. (B) Microtubules polymerized with high tubulin grow fast with large GTP-caps, resisting catastrophe. (C) Microtubules grown with XMAP215 display growth irregularities that trigger catastrophe, despite high GTP-tubulin content.