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. 2021 Aug 2;21:368. doi: 10.1186/s12872-021-02186-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Observed inflammatory and innate antiviral system gene expression contrast between patients with favorable versus unfavorable outcomes after TAVR. The composite gene expression of the 19 pre-specified pro-inflammatory genes was significantly greater in the unfavorable as compared to the favorable outcome group (0.205 log2 RNA ± SE 0.07, p < 0.01). There was no significant difference in composite gene expression of the 34 pre-specified Type 1 interferon genes (0.241 log2 RNA ± SE 0.17, p = 0.18). TAVR = transcatheter aortic valve replacement