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. 2021 Jul 30;19:226. doi: 10.1186/s12951-021-00964-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Establishment and evaluation of HFD/STZ-induced T2DM rat models. a Scheme of animal treatments. b–d Food intake, water consumption and urine volume of normal and T2DM rats at 12 weeks after STZ injection. e–f Body weight and random blood glucose levels at the time points before HFD, before STZ injection, one week after STZ injection, 6 weeks after STZ injection and 12 weeks after STZ injection. g–h Blood glucose levels during IPGTT and ITT in normal versus T2DM groups at 12 weeks after STZ injection. Data are presented as the mean ± SD. n = 5, ***p < 0.001, ****p < 0.0001