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. 2021 Aug 2;12(4):1652–1661. doi: 10.1016/j.apsb.2021.07.026

Figure 2.

Figure 2

The dePEGylated lipopeptide EKL1C showed the most potent inhibitory activity against SARS-CoV-2 PsV infection and S protein-mediated membrane fusion. (A) Inhibition of the peptides against SARS-CoV-2 PsV infection in Huh-7 cells (a), 293T/ACE2 cells (b), and Caco-2 cells (c). Data are presented as mean ± SD (n = 3). (B) Inhibition of the peptides against SARS-CoV-2 S protein-mediated cell–cell fusion. a: Images of SARS-CoV-2 S protein-mediated cell–cell fusion in the presence of EK1 (I), EKL1C (II), EKL1 (III), and PBS (IV). Scale bars: 200 μm. b: Inhibitory activity of the peptides on SARS-CoV-2 S protein-mediated cell–cell fusion. Data are presented as mean ± SD (n = 3).