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. 2020 Jul 16;106(8):2147–2160. doi: 10.3324/haematol.2020.253716

Figure 1.

Figure 1.

Endothelial damage in human intestinal biopsies. (A) Exemplary picture of a colon biopsy of a patient after allogeneic hematopoietic stem cell transplantation (allo-HSCT) without histologic evidence of acute graft-versus-host disease (aGvHD) and low level of endothelial apoptosis. The white dotted lines indicate vessel lumen and the arrow indicates one apoptotic caspase 3 positive (Casp3+) endothelial cell. (B) Exemplary picture of a colon biopsy of a patient with grade III-IV intestinal aGvHD and increased endothelial apoptosis. The white dotted lines indicate vessel lumen and the arrows indicate apoptotic Casp3+ endothelial cells. (C) Quantification of Casp3+ events in duodenal endothelium of allo-HSCT recipients given in percent of vessels in high-power fields (HPF). (D) Quantification of Casp3+ events in colonic endothelium of allo-HSCT recipients given in percent of vessels in HPF. Percentage of Casp3+ vessels was tested for significance by Student’s t-test (***P<0.001; n=7-11 patients per group). Error bars indicate mean ± standard error of the mean.