Figure 2.

Overview of current multi-targeted chimeric antigen receptor T-cell approaches. Multi-targeting may be a mean to improve efficacy of CAR-T. Three major methods could be exploited: OR-gate (tandem) CAR-T: consist of the expression of two different CAR on the same T cell; dual-target CAR-T: consist of encoding two different target specific single-chain variable fragment antibodies on same CAR protein using a single vector; CARpool: involves production of two separate single target CAR-T products infused together or sequentially.