Table 1:
Association between individual single nucleotide polymorphisms and response to hot flash treatment
| Gene | Polymorphisma | Functional Consequence | Treatment Type: Acupuncture (N=57) | Treatment Type: Pill (N= 51) | ||||
|---|---|---|---|---|---|---|---|---|
| Participants N (%) | Responders N (%) | p-valueb | Participants N (%) | Responders N (%) | p-valueb | |||
| ADORA1c | rs41264025 | Exon 3′-UTRg variant | 0.14 | 0.28 | ||||
| GG | 52 (91) | 27 (56) | 42 (89) | 16 (40) | ||||
| GA | 5 (9) | 5 (100) | 5 (11) | 0 (0) | ||||
| rs16851029 | Exon 3′-UTRg variant | 1.00 | NA | |||||
| TT/GT | 55 (98) | 30 (59) | 48 (100) | 17 (37) | ||||
| GG | 1 (2) | 1 (100) | 0 (0) | 0 (0) | ||||
| rs12744240 | Exon 3”-UTRg variant | 0.13 | 0.71 | |||||
| GG | 48 (84) | 25 (56) | 40 (78) | 14 (36) | ||||
| GT | 9 (16) | 7 (88) | 11 (22) | 4 (44) | ||||
| COMTd | rs6269 | Intron variant | 0.17 | 0.15 | ||||
| AA/GG | 30 (53) | 15 (52) | 21 (42) | 10 (50) | ||||
| GA | 27 (47) | 17 (71) | 29 (58) | 8 (28) | ||||
| TCL1Ae | rs2369049 | Intron variant | 0.38 | 0.62 | ||||
| AA/AG | 51 (89) | 27 (57) | 43 (88) | 15 (36) | ||||
| GG | 6 (11) | 5 (83) | 6 (12) | 2 (50) | ||||
| TRPV1f | rs8065080 | Missense variant | 0.26 | 0.37 | ||||
| TT | 21 (38) | 14 (70) | 20 (42) | 9 (45) | ||||
| CT/CC | 35 (62) | 17 (53) | 28 (58) | 8 (31) | ||||
a.
rs, reference sequence
b.
Fisher’s Exact Test. Outcome is dichotomized hot flash composite score responder (>50% reduction in hot flashes) at end of treatment.
c.
ADORA1, Adenosine A1 Receptors
d.
COMT, Catechol-O-methyltransferase
e.
TCL1A, T-cell leukemia 1A
f.
TRPV1, Transient Receptor Potential Cation Channel Subfamily V Member 1
g.
3’-UTR, three prime untranslated region