Table 1: Relationship of outcome to clinical parameters and molecular subtypes in cohort-1, the Oncomine-dataset, and TCGA.

Univariate analysis (single parameter logistic regression) was performed to evaluate the ability of clinical parameters and molecular subtypes to associate with metastasis, CSS, OS and RFS. Units odds ratio (OR) and 95% CI (CI) are shown for significant parameters.

Cohort-1
	Metastasis			CSS Indicator
Parameter	χ2	P value	OR; 95% CI	χ2	P value	OR; 95% CI
Age	0.02	0.885		0.49	0.484
Sex	0.54	0.462		0.29	0.590
T-Stage	7.17	0.007	1.2; 1.1 – 1.4	6.76	0.009	1.2; 1.04 – 1.3
N-stage	5.15	0.023	7.5; 1.3 – 42.8	6.33	0.012	9.4; 1.6 – 53.6
CIS	0	0.995		0	0.994
MCG-1	0.23	0.629		0.86	0.354
Oncomine-dataset
	CSS Indicator			OS Indicator
Parameter	χ2	P value	OR; 95% CI	χ2	P value	OR; 95% CI
Age	3.06	0.080		1.07	0.301
Sex	0.02	0.894		0.06	0.806
T-stage	11.43	0.0007	1.1; 1.04 – 1.2	9.2	0.002	1.1; 1.04 – 1.2
N-stage	8.84	0.003	3.4; 1.5 – 7.5	1.55	0.213
M-stage	0	0.998		5.38	0.020	11.9; 1.5 – 96.1
MCG-1	0.06	0.808		0.98	0.323
TCGA-dataset
	RFS Indicator			OS Indicator
Parameter	χ2	P value	OR; 95% CI	χ2	P value	OR; 95% CI
Age	0.17	0.682		15.5	< 0.0001	1.04; 1.02 – 1.06
Sex	0	0.945		0.67	0.414
Grade	3.67	0.056		7.44	0.006	7.8; 1.8 – 34.1
T-stage	4.23	0.04	1.04; 1.0 – 1.1	18.8	< 0.0001	1.08; 1.04 – 1.1
N-stage	13.95	0.0002	2.8; 1.6 – 4.9	31.1	< 0.0001	3.6; 2.3 – 5.7
LVI	3.16	0.076		11.8	0.0006	2.4; 1.5 – 3.9
M-stage	0.98	0.323		4.44	0.035	4.3; 1.1 – 16.8
MCG-1	2.28	0.131		5.5	0.019	1.3; 1.04 – 1.5
MCG-Ext	0.68	0.410		8.36	0.004	1.3; 1.1 – 1.6
Consensus	4.78	0.029	1.2; 1.02 – 1.4	23.26	< 0.0001	1.3; 1.2 – 1.5
TCGA-2017	0.98	0.323		10.65	0.001	1.4; 1.1 – 1.6
Lund-Taxonomy	1.1	0.294		8.05	0.005	1.3; 1.1 – 1.5