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. Author manuscript; available in PMC: 2021 Aug 2.
Published in final edited form as: J Urol. 2019 May 21;203(1):62–72. doi: 10.1097/JU.0000000000000351

Table 4: Multivariate analysis to determine relationship of outcome to clinical parameters and molecular subtype classifications in the TCGA-dataset.

In all analyses we performed Cox Proportional Hazards Model with stepwise selection procedure to determine the final model that accurately describes the outcome. The parameters included in each analysis were: Age, sex, T-stage, N-stage, M-stage, LVI, and subtype classification. Only significant parameters based on Wald’s test with overall hazard ratio (HR) and 95% CI are shown.

TCGA dataset OS Indicator
MCG-1 Consensus TCGA-2017 Lund-Taxonomy
Parameter P value HR; 95% CI P value HR; 95% CI P value HR; 95% CI P value HR; 95% CI
LVI 0.003 2.7; 1.4 – 5.3 0.003 2.7; 1.4 – 5.3 0.016 2.3; 1.2 – 4.7 0.003 2.7; 1.4 – 5.3
Subtype Classification 0.045 4.4; 1.1 – 16.5
TCGA dataset RFS Indicator
MCG-1 Consensus TCGA-2017 Lund-Taxonomy
Parameter P value HR; 95% CI P value HR; 95% CI P value HR; 95% CI P value HR; 95% CI
N-stage 0.039 2.1; 1.04 – 4.2 0.039 2.1; 1.04 – 4.2 0.039 2.1; 1.04 – 4.2 0.039 2.1; 1.04 – 4.2

Note: Analysis of only HG specimens yields the same values.